Age at first trauma is associated with serotonin 1B receptor reductions and comorbid depression in posttraumatic stress disorder

Abstract

ACKNOWLEDGMENTS Data presented in mean ± standard deviation, unless otherwise indicated. P values determined by independent sample t-tests or ANOVA followed by Tukey’s post-hoc test for continuous variables, or by chi-square for dichotomous variables. 1Post-hoc PTSD > HC, p=0.002. 2Physical assault includes sexual assault, domestic violence and other non-combat related physical violence. 3Traumatic experiences included meet DSM-IV-TR criteria A for PTSD. 4Post-hoc PTSD > HC, p TC, p<0.001. AA, African-American; AS, Asian-American; BMI, body mass index; C, Caucasian; F, female; H, Hispanic; M, male; MDD, major depressive disorder; MDE, major depressive episode; N, nonsmoker; S, smoker. Significant group differences in [11C]P943 BPND within a cortico-striatal-limbic circuit initially established by multivariate analysis of variance including the 5 a priori ROIs (Wilks' Lambda F[10,178]=2.18, p=0.021). F-statistic and P values in table determined by subsequent one-way ANOVA for each ROI. Data presented in mean ± standard deviation, unless otherwise indicated. Tukey’s HSD Post-hoc t-tests and % differences as follows: Anterior Cingulate Cortex: PTSD < Healthy Control (9.1%, p=0.048)*, Trauma Control = Healthy Control (p=0.095), PTSD = Trauma Control (p=0.98) Amygdala: PTSD < Healthy Control (10.9%, p=0.047)*, Trauma Control < Healthy Control (14.7%, p=0.027)*, PTSD = Trauma Control (p=0.74) Caudate: PTSD < Healthy Control (18.8%, p=0.006)*, Trauma Control < Healthy Control (25.8%, p=0.002)*, PTSD = Trauma Control (p=0.56)