Abstract
Fluoride (F) ingestion is well known to be associated with oxidative stress in experimental animals, but the precise mechanism of its toxicity associated with advancing age has not yet been delineate. The present study attempts to assess the learning and memory capacity of rats using water maze test for cognitive functioning. The markers of oxidative stress i.e., Reacting oxygen species (ROS), protein carbonyl content (PC), lipid peroxide levels (LPx), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) were measured in the brain hippocampus of young and aged rats fed with fluoride (100 ppm) with drinking for 90 days. We observed significant changes of fluoride treated young and aged rat as compared with their respective controls. Lipofuscin content was significantly increased in fluoride treated aged rats. Ultra structural studies of the CA1 region in hippocampus of fluoride exposed rats revealed that the changes were more pronounced in the aged treated rats in terms of presence of clustered lipofuscin, vacuolization, lysosomal degradation and nucleolar fragmentation. On the basis of the results it may conclude that fluoride may be linked with neuro lipofuscinogenesis and alteration in neurobehavioral activity and these changes may be responsible for the development of age related disorders.
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