Age‐associated effect of freeze‐dried grape powder on inflammatory markers and physical activity in adults with knee osteoarthritis (1025.8)

Abstract

Osteoarthritis (OA) is the most common joint disease among US adults, leading to pain and disability. Treatment ranges from symptom management to joint replacement, leading many to seek natural dietary approaches. Grapes, rich in anti‐inflammatory polyphenols may aid in management of OA symptoms. The purpose of this study was to assess the effect of grape consumption on physical activity, biochemical markers of inflammation (IL1‐β) and cartilage metabolism (COMP). A total of 72 men and women with knee OA were recruited and randomized. Group 1 (n=28, 21 female) consumed 47 grams of freeze‐dried grape powder (FDGP) daily for four months. Group 2 (n=28, 21 female) consumed 47 grams of a comparable placebo. Self‐reported physical activity and serum specimens were obtained at baseline and at four months. There was a significant decrease in very hard activity in the placebo group. However, a 70 % increase was seen in very hard activity for those <64 yr. in the FDGP group. Participants >65 yr. reported a significant decline in moderate and hard activities (P<.05) in both groups. A statistically significant increase in IL1‐β was observed in both groups, males > females. A greater increase occurred in the placebo group (637.33%) vs. FDGP (194.64%). Levels of IL‐1β and COMP increased more in those >65 yr. Both groups had a statistically significant increase in COMP (154.2% FDGP vs. 172.27% placebo). Longer treatment duration with FDGP may be necessary to see benefits on physical activity levels in this population.Grant Funding Source: Supported by California Table Grape Commission