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Abstract
Contrary to the earlier light microscopic studies, electron microscopic investigation on 11 male guinea pigs revealed marked accumulation of lipofucsin pigment in the hypothalamic neurons with the passage of time. Even in 6 month guinea pigs scattered pigment bodies were noted. Two types of pigment granules have been observed in the aged animals. Dimethylaminoethyl p-chlorophenoxyacetate caused a marked diminution of the electron density and reduction in the size and number of the pigment granules. Furthermore, histochemical examination revealed a marked diminution of acid phosphatase activity in the treated group of animals as compared to normal “control”. But the α-esterase and succinic dehydrogenase activity was found to be increased following drug treatment.
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