Abstract
<p>Bone density alterations are often reported in patients with solid tumors and hematologic malignancies except cases of Hodgkin lymphoma, when this problem remains understudied. The aim of this study was to investigate the significance of patients’ age and ABVD standard chemotherapy regimen as the determinants of vertebral trabecular bone tissue status changes. The study included 40 HL patients of different age groups (median age 35.38 ± 2.22). Densitometric and structural parameters were obtained from pre-treatment and after chemo CT scans. Analysis of these parameters after chemotherapy compared to the initial values revealed significant decrease of bone density (maximum up to 24.9 %) in all age groups, as well as in patients who were treated with ABVD regimen. Structural parameters values (BV/TV, SMI, BS, FD, textural parameters) had also suggested trabecular transformation dependent on patients’ age and chemotherapy treatment. Age and ABVD standard chemotherapy may be considered as predisposing risk factors for trabecular bone structural alteration and there is a need for timely diagnosis and prevention.</p>
Highlights
Patients with solid tumors, acute and chronic leukemias are more commonly diagnosed with bone density alterations, only a few studies have been published exploring the dynamics of bone mineral density in Hodgkin lymphoma (HL) patients [9,10]
The aim of the work was to investigate the impact of age as a determinant of VTB changes; to explore the VTB changes in Hodgkin lymphoma patients at the diagnostics and after treatment with ABVD chemotherapy regimen
We conducted a comparative analysis of bone density changes (HU units) at the diagnostics and after completion of chemotherapy in male, female and common group
Summary
Acute and chronic leukemias are more commonly diagnosed with bone density alterations, only a few studies have been published exploring the dynamics of bone mineral density in Hodgkin lymphoma (HL) patients [9,10]. Several studies have reported bone mineral density changes in patients with HL [2], there are no prospective studies indicating the impact of age and chemotherapy regimen on vertebral trabecular bone status (VTBS) and it remains unclear. The aim of the work was to investigate the impact of age as a determinant of VTB changes; to explore the VTB changes in Hodgkin lymphoma patients at the diagnostics and after treatment with ABVD chemotherapy regimen
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