Abstract
Both New Zealand white (NZW) and black (NZB) mice develop a form of clinically silent glomerulonephritis. In the former, the renal lesion is more pronounced in females and results from the deposition of immune complexes in glomeruli. The most prominent features of the lesions are deposits of immune complexes in the mesangium and an increase in the number of cells in glomeruli. More advanced lesions consisted of complexes in the peripheral capillary wall. By contrast, NZB mice showed only minimal sex differences; furthermore, their lesions were less advanced than in the NZW females. These data show that renal disease in the NZB/W hybrid is most similar to nephritis of the female NZW mouse.
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