Abstract
Summary Aging is known to involve changes in the neurochemistry of catecholaminergic and serotonergic components of the brain. With regard to the serotonin precursor L-tryptophan, the experiments performed in this study show that, independently of the age and sex of the animals the greatest tryptophan uptake is constantly seen in the lower brainstem, corpora striata, amygdala-hippocampus and hemispheres. However, tryptophan accumulation by the brain is more active in some brain areas of old female rats than in those of their old male mates.
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