Abstract

PurposeTo investigate the relationship between various characteristics of a normal population and laser speckle flowgraphy (LSFG) measurements of mean blur rate (MBR) in the optic nerve head (ONH).MethodsA total of 189 eyes of 189 normal subjects (93 male, 96 female, mean age 45 ± 14 years old, age range: 20–72) without any history of hypertension, hyperlipidemia or diabetes were enrolled. ONH microcirculation was measured with LSFG and overall MBR (MA), vessel-area MBR (MV), and tissue-area MBR (MT) were derived from these measurements. The statistical association of these measurements with characteristics such as sex, age, intraocular pressure (IOP) and systolic blood pressure (SBP) was then determined.ResultsThere was a trend towards decreased IOP and MV and increased SBP with age (P = 0.002, P = 0.035, and P = 0.006, respectively). Furthermore, IOP, MV and SBP were correlated with age (r = -0.23, P = 0.011; r = -0.24, P < 0.001; and r = 0.30, P < 0.001, respectively). Separate multiple regression analyses of independent contributing factors revealed that sex and IOP contributed to MA (P < 0.001 and P = 0.002, respectively), sex, IOP, and age contributed to MV (P < 0.001, P = 0.003, and P = 0.024, respectively), while only IOP contributed to MT (P = 0.003).ConclusionIn a normal population, MBR was affected by IOP in both the large vessel and capillary areas of the ONH, but not by SBP. MV was also affected by age and sex, while MT was stable independent of age or sex.

Highlights

  • Ocular diseases related to ischemia, such as diabetic retinopathy, and ocular diseases related to circulatory disturbances and axonal damage, such as glaucoma, are the main causes of blindness worldwide.[1,2,3,4] They are common in industrialized countries, and their successful treatment is a goal of public health

  • There was a trend towards decreased intraocular pressure (IOP) and MV and increased systolic blood pressure (SBP) with age (P = 0.002, P = 0.035, and P = 0.006, respectively)

  • Separate multiple regression analyses of independent contributing factors revealed that sex and IOP contributed to MA (P < 0.001 and P = 0.002, respectively), sex, IOP, and age contributed to MV (P < 0.001, P = 0.003, and P = 0.024, respectively), while only IOP contributed to MT (P = 0.003)

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Summary

Introduction

Ocular diseases related to ischemia, such as diabetic retinopathy, and ocular diseases related to circulatory disturbances and axonal damage, such as glaucoma, are the main causes of blindness worldwide.[1,2,3,4] They are common in industrialized countries, and their successful treatment is a goal of public health. It is important to find new ways of studying these diseases and identifying them in patients. This calls for the development of new, noninvasive methods to measure ocular blood flow in living eyes. It uses the laser speckle phenomenon to detect and analyze ocular blood flow, and can quantify ocular circulation in vivo. A recently developed LSFG measurement parameter, mean blur rate (MBR), can serve as a quantitative index of retinal blood cell speed. The impact on MBR of age-related alterations in blood flow in the vascular and tissue regions of the ONH has not yet been determined.[14]

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