Abstract
Among the many factors considered relevant to hypertension, obesity and metabolic disturbances play an important role in the development of this pathology. Therefore, lipid accumulation product (LAP), an index of visceral adiposity, is a simple and effective indicator of hypertension risk. To date, the reference and cut-off values for LAP have not been defined. The aim of the study was to determine the age-adjusted optimal cut-off values of LAP for the prediction of hypertension risk. This cross-sectional case–control study comprised 1960 subjects ranging from 20 to 64 years of age. The participants underwent anthropometric tests, blood pressure measurements, questionnaire surveys and laboratory examinations. The cut-off values of LAP were determined using receiver operating characteristic (ROC) curve analysis. According to our study results, LAP values in healthy subjects increased with age, whereas there was no effect of age on LAP values in patients with hypertension. These two findings determine the presence of age-adjusted cut-off values of LAP for diagnosing hypertension. Increasing age is associated with an increase in the cut-off values of LAP to detect hypertension. In conclusion, hypertension risk should be estimated using the age-adjusted cut-off values of LAP; otherwise, the risk of hypertension might be overestimated or underestimated.
Highlights
Lipid accumulation product (LAP) is a current marker of visceral obesity and is based on a combination of two variables, waist circumference (WC) and fasting concentration of triglycerides (TG)
The area under the receiver operating characteristic (ROC) curve (AUROC) value of lipid accumulation product (LAP) for defining hypertension in the whole study group of women was 0.785, and the cut-off value of LAP was 27.0 cm mmol /l with 70.6% sensitivity and 75.8% specificity (Table 3)
The main finding of this study is that the optimal cut-off values of LAP for diagnosing hypertension vary with age
Summary
Lipid accumulation product (LAP) is a current marker of visceral obesity and is based on a combination of two variables, waist circumference (WC) and fasting concentration of triglycerides (TG). LAP could be a good marker to predict hypertension because it is classified as a mixed index calculated from WC and fasting TG levels, which reflect accumulated and circulating fat, respectively. The optimal LAP cut-off point for identifying hypertension has not yet been determined. The cut-off values of LAP for hypertension obtained in some studies are very different. Reported LAP cut-off values ranged from 25.16 to 31.59 cm mmol/l for women and from 20.10 to 63.89 cm mmol /l for men[9,10,11,12] These discrepancies may be due to differences in sample populations with regard to age range, race/ethnicity, criteria for screening hypertension, and health status of the control group. The aim of the study was to determine the age-adjusted optimal cut-off values of LAP for the prediction of hypertension risk
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