Abstract
The effects of metallic nanoparticles as cytotoxicity or antibacterial activity are widely known. It is also obvious that ultrasound is one of the most widely used therapeutic modalities in medicine. The effect of application of therapeutical ultrasonic field in the presence of metallic nanoparticles AgCu <100 nm modified by phenanthroline or polyvinyl alcohol was examined on human ovarian carcinoma cells A2780. Metallic nanoparticles were characterized by electron microscopy and by measuring of zeta potential. The cell viability was tested by MTT test. The experimental results indicate a significant decrease of cell viability, which was affected by a combined action of ultrasound field and AgCu nanoparticles. The maximum decrease of cells viability was observed for nanoparticles modified by phenanthroline. The effect of metallic nanoparticles on human cell in presence of ultrasound exposure was found—a potential health risk or medical advantage of targeted therapy in the future.
Highlights
Ultrasound is widely used in medicine and represents a large percentage of all imaging methods
The effect of application of therapeutical ultrasonic field in the presence of metallic nanoparticles AgCu
The experimental results indicate a significant decrease of cell viability, which was affected by a combined action of ultrasound field and AgCu nanoparticles
Summary
Ultrasound is widely used in medicine and represents a large percentage of all imaging methods. The possibility of targeted delivery of substances into cells using ultrasonic field has been established, both in drugs and in other macromolecular substances [3, 4]. The still unsolved question is the effect of ultrasound on penetration of particles of nanometer scale into the intracellular space. This question is generally associated with particular risks of toxicity of nanoparticles, but it can be seen as a solution to some cancer treatment in the form of targeted therapy. The mechanism of ultrasound action in the cited works is nonthermal and it is explained by the following scheme: the oscillation and destruction of cavitation microbubbles as well as microstreaming and radiation forces are considered to be responsible for the transient rupture of vascular barriers and subsequent increase in the tumor’s vascular permeability
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