Abstract
Measuring myocardial contractility is indispensable for exploring cardiac pathogenesis and quantifying drug efficacy. Among the biosensing platforms developed for detecting the weak contractility of a single layer of cardiomyocytes (CMs), thin brittle metal membrane sensors with micro-cracks are highly sensitive. However, the poor stability limits their application in long-term measurement. Here, we report a high-stability crack sensor fabricated by depositing a 105 nm-thick Ag/Cr with micro-cracks onto a carbon nanotubes-polydimethylsiloxane (CNT-PDMS) layer. This novel brittle-tough bilayer crack sensor achieved high sensitivity (gauge factor: 108,241.7), a wide working range (0.01% - 44%), and high stability (stable period > 2,000,000 cycles under the strain caused by a monolayer of CMs). During 14-day continuously monitoring CMs culturing and drug treatment testing, the device demonstrated high sensitivity and stability to record the dynamic changes caused by contractility of the CMs.
Published Version
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