Agastache foeniculum (Pursh) KunTze - chemical composition and bioactivity

Abstract

Aim: Research of chemical composition and bioactivity of Agastache foeniculum (Pursh) Kuntze. Materials and Methods: Two literary databases (PubMed and Science Direct) were explored. Main results: The results of the database on the Internet revealed the presence of two groups of biologically active substances in the essential oil: 1. Main volatile compounds: phenylpropanoic and terpene derivatives (estragolе, methyl eugenol, pulegone, menthol and isomenthol); 2. Main non-volatile compounds: derivatives of caffeic acid and rosmarinic acid; flavonoids: acacetin and its 3-O-glycoside tilianin; lignans: agastenol and agastinol, diterpenes and triterpenoids, carotenoids, sterols. The plant is used against gastritis, liver, bile and kidney diseases, headaches and alleviates menstrual pain and pain in facial paralysis. It helps strong recovery after nerve disorders, acts favorably even in the treatment of victims of radiation. The traditional Chinese medicine considers the plants as a symbol of youth and beauty. Preclinical and Clinical studies of bioactivity of the plant extracts established antimicrobial and antiviral effects, activity, anti-inflammatory and hypocholesterolemic effects, antioxidant and anticancer activity. Conclusion: Anise is rich in biologically active substances that have various biological effects. There is a need of more in-depth phytochemical studies to identify the single compounds and their biological effects, and possible applications in the medical practice.