Abstract
Since Agaricus blazei Murill (AbM) extract reduced specific IgE and ameliorated a skewed Th1/Th2 balance in a mouse allergy model, it was tested in blood donors with self-reported, IgE-positive, birch pollen allergy and/or asthma. Sixty recruited donors were randomized in a placebo-controlled, double-blinded study with pre-seasonal, 7-week, oral supplementation with the AbM-based extract AndosanTM. Before and after the pollen season, questionnaires were answered for allergic rhino-conjunctivitis, asthma, and medication; serum IgE was measured, and Bet v 1-induced basophil activation was determined by CD63 expression. The reported general allergy and asthma symptoms and medication were significantly reduced in the AbM compared to the placebo group during pollen season. During the season, there was significant reduction in specific IgE anti-Bet v 1 and anti-t3 (birch pollen extract) levels in the AbM compared with the placebo group. While the maximal allergen concentrations needed for eliciting basophil activation before the season, changed significantly in the placebo group to lower concentrations (i.e., enhanced sensitization) after the season, these concentrations remained similar in the AndosanTM AbM extract group. Hence, the prophylactic effect of oral supplementation before the season with the AbM-based AndosanTM extract on aeroallergen-induced allergy was associated with reduced specific IgE levels during the season and basophils becoming less sensitive to allergen activation.
Highlights
Agaricus blazei Murill (AbM) is a Brazilian relative of champignon, and Hericium erinaceus and Grifola frondosa from Asia are all medicinal Basidiomycetes mushrooms used as health food and against cancer [1,2,3]
We have recently found that AndosanTM in drinking water has antitumor effects in a mouse model for colorectal cancer [11]
We examined whether the AbM-based mushroom extract AndosanTM, taken orally before the pollen season, could reduce allergy and asthma symptoms, medication, and specific immunoglobulin E (IgE) basophil sensitization to t3 and Bet v 1 and could influence the Th1/Th2 cytokine balance in otherwise healthy humans as found in mouse models for allergy and asthma [9,10]
Summary
Agaricus blazei Murill (AbM) is a Brazilian relative of champignon, and Hericium erinaceus and Grifola frondosa from Asia are all medicinal Basidiomycetes mushrooms used as health food and against cancer [1,2,3] Their antitumor properties are partly immunomodulatory via stimulation by, e.g., β-glucans of monocytic, natural killer (NK), and T helper 1 cells [4,5,6,7]. We have recently found that AndosanTM in drinking water has antitumor effects in a mouse model for colorectal cancer [11] Both anti-allergic/-asthmatic and antitumor properties have been demonstrated in vivo for AbM given enterally
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