Abstract
New cyclic hepta- and octapeptide, agardhipeptins A ( 1) and B ( 2), were isolated from the cyanobacterium Oscillatoria agardhii (NIES-204). The structures of 1 and 2 were elucidated to be cyclo(-His 1-Gly 2-Trp 3-Pro 4-Trp 5-Gly 6-Leu 7-) and cyclo(-Trp 1-Leu 2-Pro 3-Trp 4-Ala 5-Pro 6-Trp 7-Val 8-), respectively, by extensive 2D NMR data and chemical degradation. Agardhipeptin A ( 1) inhibited plasmin with an IC 50 of 65 μg/mL but agardhipeptin B ( 2) had no inhibitory activity.
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