Abstract
The ability to manipulate the structure and function of promising systems via external stimuli is emerging with the development of reconfigurable and programmable multifunctional materials. Increasing antifungal and antitumor activity requires novel, effective treatments to be diligently sought. In this work, the synthesis, characterization, and in vitro biological screening of pure α-Ag2WO4, irradiated with electrons and with non-focused and focused femtosecond laser beams are reported. We demonstrate, for the first time, that Ag nanoparticles/α-Ag2WO4 composite displays potent antifungal and antitumor activity. This composite had an extreme low inhibition concentration against Candida albicans, cause the modulation of α-Ag2WO4 perform the fungicidal activity more efficient. For tumor activity, it was found that the composite showed a high selectivity against the cancer cells (MB49), thus depleting the populations of cancer cells by necrosis and apoptosis, without the healthy cells (BALB/3T3) being affected.
Highlights
Silver nanoparticles (Ag NPs), are considered one of the most important members of the noble metal NPs family
Four samples were studied: pure α-Ag2WO4, a composite irradiated with electrons (Ag NPs/α-Ag2WO4:E), a composite irradiated by a fs laser beam under non-focused conditions (Ag NPs/αAg2WO4:NF), and a composite irradiated by a fs laser beam under focused conditions (Ag NPs/α-Ag2WO4:F)
The samples present an orthorhombic structure with a space group of Pn2n and eight molecules per unit cell (Z = 8), according to the crystallographic data sheet n° 2489692 in the Inorganic Crystal Structure Database (ICSD)
Summary
Silver nanoparticles (Ag NPs), are considered one of the most important members of the noble metal NPs family. Resonance effects, a Schottky contact additional active sites and/or presence of electronics traps[31,32,33], that in the end are used to enhance localized heating in living systems, wich may find potential applications in thermal ablation therapies or drug delivery mechanisms[34] In this context, a highly attractive semiconductor for its photochemical activity is α-Ag2WO4. From a medical point of view, the development of novel composites as antimicrobials is very attractive, owing to the worldwide crisis of bacterial resistance to conventional, narrow-target antibiotics
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