Abstract
Ag/F Tio2 Nanoparticles activity against algD and plcH Genes of Pseudomonas aeruginosa Isolated from Patients with Cystic Fibrosis in Al Muthanna City
Highlights
Silver nanoparticles are considered antimicrobial,potency agents to treat and inhibit the bacterial infection
The conventional PCR was used to screen for many different virulent genes and eventually, the only algD and plcH were detected among 11 Pseudomonas aeruginosa strains over of twenty isolates of P. aeruginosa isolated from patients with cystic fibrosis (CF) disease
The Ag/F Tio[2] NPs was used as antibacterial to test the AgNPs activity against the expression of algD and plcH genes that are screened as a common complication of gene virulence in the cystic fibrosis (CF) disease
Summary
Silver nanoparticles are considered antimicrobial,potency agents to treat and inhibit the bacterial infection. It has been utilizedas antibacterial against multidrug resistant bacteria such as P. aeruginosa[1]. The infection with Cystic fibrosis (CF) is caused by many microorganisms such as pathogenic bacteria and fungal bacteria or fungi causes the inflammation leading to destruction of the lungs and death. The mutation into conductance gene (CFTR), encoding for a membrane protein, involved in electrolytes transport This type of mutation is leading to the destruction of epithelial cell function as the production of a result of sticky and bronchial secretions[6,22,23]. The P. aeruginosa is often the nosocomial bacteria as well as is multidrug resistance bacteria against many antibiotics such as fluoroquinolones, aminoglycosides and cephalosporin due to acquisition of different mechanisms for antibiotics resistance[10,11]
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