Abstract
Background Systolic circumferential and longitudinal strain(CSt%, LSt %) are widely used to assess myocardial performance, but their afterload dependence has not been well characterized. Using geometric estimates of left ventricular (LV) circumferential and meridional wall stress(CWS, MWS) as indices of afterload at the myocardial level, we compared LV CSt and LSt to estimates of CWS and MWS in normals (NL, n= 39, 46% female, age 54.6+/-14.6 yrs) and patients with dilated cardiomyopathy (DCM, n= 35, 23% female, age 50.8+/-15.0 yrs, EF 27.2+/-10.8%). Methods
Highlights
Systolic circumferential and longitudinal strain(CSt%, LSt %) are widely used to assess myocardial performance, but their afterload dependence has not been well characterized
Mean mid-left ventricular (LV) CSt% was -22.2+/-4.8% in NL but markedly reduced in DCM (-9.3+/-5.0%, p< 0.0001) while mean mid-LV LSt% was -14.7/-+8.9 in NL and markedly reduced in DCM(-8.6+/-4.6, p< 0.0006)
If NL LV myocardium were exposed to the same afterload(CWS) as in DCM, mean CST% might fall from -22.3% to -12.1%
Summary
Systolic circumferential and longitudinal strain(CSt%, LSt %) are widely used to assess myocardial performance, but their afterload dependence has not been well characterized. Using geometric estimates of left ventricular (LV) circumferential and meridional wall stress(CWS, MWS) as indices of afterload at the myocardial level, we compared LV CSt and LSt to estimates of CWS and MWS in normals (NL, n= 39, 46% female, age 54.6+/-14.6 yrs) and patients with dilated cardiomyopathy (DCM, n= 35, 23% female, age 50.8+/-15.0 yrs, EF 27.2+/-10.8%)
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