Abstract
Aflatoxin produced from few molds as Aspergillus flavus, A. parasiticus and A. nomius is highly carcinogenic, mutagenic to the animals and humans. These molds are present in the dietary intake of cattle feed. Present investigation was performed to observe the carryover of AFB1 to the milk toxin of lactating cows. Cows during early lactation stage yields more milk compared to late lactating stage, hence, the same cows were used to keep the variable of physiology of cows as nearly constant. AFM1 concentration was found independent to the intake of AFB1 with the compound foods ingested by cows. Carryover of aflatoxin was observed comparatively less in case of cows of late lactation stage. With the yield of milk per day (milking twice), the carryover rate also varied. AFM1 concentration was observed within the limit as set by EU. Frequent evaluation and testing of milk is necessary.
Highlights
Mycotoxins are secondary metabolites produced by some toxigenic fungi under conducive conditions of temperature and humidity [1]
Aflatoxin M1 is less poisonous than aflatoxin B1, and according to the International Agency for Research on Cancer (IARC) classification, aflatoxin B1 and M1 were classified as group 1 and 2 of the human carcinogens, respectively [2], [4]
The presence of AFM1 in the milk of the cows is a result of carryover by the ingestion of AFB1 contaminated feed
Summary
Mycotoxins are secondary metabolites produced by some toxigenic fungi under conducive conditions of temperature and humidity [1]. Aflatoxin M1, known as milk toxin, is a hydroxyl metabolite of aflatoxin B1, metabolized in the liver of cattle and is being secreted in bile, urine, dung and in milk of lactating cattle [3], [4]. These toxins can cause carcinogenic, mutagenic, teratogenic and immunosuppressive effect on many animal species including human. Consumption of AFM1 contaminated milk (exceeding the regulatory limit of USFDA, EU and CAC) can adversely affect the health of children, old and weak and susceptible people
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