Abstract
Effects of single oral doses of aflatoxin B 1 (2 mg/kg) to monkeys Macaco irus on total liver protein synthesis and accumulation of liver lipid were investigated. Incorporation of [ 14C]leucine into total liver protein in vivo was inhibited 50 per cent by aflatoxin B 1 3 hr after oral administration. This degree of inhibition was maintained up to 13 hr. Concomitant with this change there was an extensive disaggregation of polysomes in liver preparations. A progressive accumulation of lipid in liver following single dose administration of aflatoxin B 1 was observed. This increase in liver lipid was primarily triglyceride. The role of aflatoxin induced inhibition of hepatic protein synthesis in vivo to increase liver lipid is discussed.
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