Affinity-based clonal selection in Peyer's patches.

Abstract

Effective long-lasting immunity depends on the generation of protective antibodies that restrict the invasion of harmful pathogens. The germinal center (GC) is a microanatomical site at which B cells acquire random somatic mutations in their immunoglobulin genes followed by affinity-based selection. Whereas this process was extensively studied in lymph nodes and spleen, less is known about GCs located in mucosal tissues lymphoid organs, such as the Peyer's patches (PPs). These lymphoid organs have a special structure and host a unique niche known as the subepithelial dome (SED), where B cell activation and class switch recombination to IgA take place before GC seeding. As opposed to typical lymph-nodes, the PPs host chronic GC reactions that are driven by gut-bacteria. Direct evidence for antibody affinity maturation in PPs, and competition between B cells for T cell help was recently obtained. Here, we discuss these findings and how they complement each other.