Affective temperament in inflammatory bowel diseases: Another brick in the wall of differentiation.

Maciej Bieliński,Natalia Lesiewska,Ariel Liebert,Joanna Bielińska,Bartosz Brzoszczyk,Maria Kłopocka,Artur Mieczkowski,Paulina Sopońska-Brzoszczyk,Alina Borkowska,Marco Innamorati

doi:10.1371/journal.pone.0205606

Maciej Bieliński, Natalia Lesiewska + Show 8 more

Open Access

https://doi.org/10.1371/journal.pone.0205606

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Journal: PloS one	Publication Date: Nov 1, 2018
Citations: 7	License type: CC BY 4.0

Affiliation: Nicolaus Copernicus University

Abstract

Psychiatric disorders are significantly common complications among patients suffering from inflammatory bowel diseases (IBD). Affective temperament is a concept of core personality traits, which can decribe the vulnerability to mood disorders, therefore its evaluation might convey useful information about patients' mental status in autoimmune disorders. The aim of the study was to evaluate the affective temperament in patients with Crohn's disease (CD) and ulcerative colitis (UC) as characteristic features of these diseases, but also in the clinical course and the severity of anxiety and depression.Due to our knowledge this is the first study of this kind. The study enrolled 130 patients with IBD, including 68 with CD and 62 with UC. We used TEMPS-A to evaluate affective temperament and HADS scales to assess the intensity of depressive and anxiety symptoms. Harvey Bradshaw scale, Crohn’s Disease Activity Index (CDAI) and Mayo Score were used to evaluate clinical severity of the diseases. We observed significantly higher prevalence of depressive, cyclothymic and anxiety temperaments in CD patients compared to the control group. Harvey Bradshaw scale, CDAI and Mayo Self Report showed statistically significant outcomes, including significant positive correlations with depressive, cyclothymic and anxiety subscales of TEMPS-A, and negative correlation with the hyperthymic temperament in CD subjects. Our findings indicate significant differences between CD and UC due to temperament traits, and suggest distinct pathogenesis of mood disorders in IBD.

Highlights

Inflammatory Bowel Disease (IBD), such us Crohn’s Disease (CD) and Ulcerative Collitis (UC) are chronic and relapsing gastrointestinal disorders with crucial implications
Similar analyzes were carried out regarding the subgroup results of patients with CD and UC to the results of the control group matched according to gender, age and level of education to the patients groups (Table 3)
That results of TEMPS-A imply significant differences in the serotoninergic transmission in those two disorders. To our knowledge, this is the first study evaluating the affective temperament via TEMPS-A in both CD and UC patients

Summary

Introduction

Inflammatory Bowel Disease (IBD), such us Crohn’s Disease (CD) and Ulcerative Collitis (UC) are chronic and relapsing gastrointestinal disorders with crucial implications. This issue requires greater attention provided that the number of patients with IBD is still significantly. IBD may lead to several considerable complications associated with gastrointestinal manifestation, but can affect other relevant systems [2,3,4,5,6]. This contributes to poor quality of life (QoL) in IBD patients. According to many studies, impaired QoL depends on the disease activity [8,9]

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