Abstract
Abstract—In Hodgkin's disease, the most frequent skin lesions are non-specific and include pruritis, ichthyosis, urticaria, hyperpigmentation, erythema multiforme and erythema nodosum. Specific cutaneous involvement in Hodgkin's disease occurs in 0.5-7.5 % of diagnosed patients. This involvement often corresponds to cutaneous lesions secondary to known lymph node Hodgkin's disease, and most patients are usually in very advanced stages of the disease.We present the case of a 73-year-old woman diagnosed with lymphocyte-depletion Hodgkin's disease, stage IV, in treatment with palliative radiotherapy. The patient presented with several subcutaneous plaques in the lumbosacral region, erythematous, very infiltrated to palpation, only a few centimeters in diameter and not painful. A biopsy was performed, in which the presence of an infiltrate with anaplastic cells, lymphocytes, eosinophils, Reed-Sternberg cells and Hodgkin's cells could be seen. Immunohistochemistry studies showed positivity for CD30 and CD15 and negativity for CD45, which confirmed the specific skin involvement from the underlying disease.
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