Aestivalosides A–L, twelve pregnane glycosides from the seeds of Adonis aestivalis

Abstract

Eight adonilide (14,20α-epoxy-3β,20-dihydroxy-14β-pregn-5-en-18-oic acid γ-lactone) glycosides, named aestivalosides A–H, and four glycosides of the adonilide derivatives, named aestivalosides I–L, were isolated from the MeOH extract of seeds of Adonis aestivalis. Aestivalosides A–L were previously undescribed compounds, and were structurally characterized using spectroscopic techniques, including two-dimensional NMR, and chemical methods.