Aerosol inhalation of Xiyanpingversus ribavirin for treatment of respiratory tract infections in children：a meta-analysis of randomized controlled studies

Abstract

Objective To evaluate the efficacy of aerosol inhalation ofXiyanpingversus ribavirin for the treatment of respiratory tract infections in children.MethodsPubMed, Embase, Cochrane database of Systematic Reviews, CNKI, cqvip and wanfangdata were searched. The randomized controlled trials（RCTs） of aerosol inhalation ofXiyanpingversus ribavirin injections for the treatment of respiratory tract infections in children were incuded. The quality of trials was evaluated and data analyses were performed with the Cochrane Collaboration’s software RevMan 5.0.Results A total of 7 trials were included, involving 857 patients（437 treated withXiyanping, 420 treated with ribavirin）. Both of the clinical cure rate（50.11%vs. 40.71%） and clinical effective rate（91.08%vs. 75.95%） in theXiyanping group were significantly higher than those in the ribavirin group, withOR（95%CI） 1.49（1.13 to 1.97） and 3.54（1.87 to 6.71）, respectively.Conclusions Aerosol inhalation ofXiyanping superior to aerosol inhalation of ribavirin for the treatment of respiratory tract infections in children. Owing to the poor quality and the small sample size of included trials, more larger good quality CRTs are required to confirm this conclusion. Key words: Respiratory tract infections; Xiyanping; Ribavirin; Administration,Inhalation; Aerosols; Randomized controlled trials as topic; Child; Meta-analysis