Abstract
The aim of the study was to compare the effect of maximal exercise (ME) on paraoxonase (PON) and arylesterase (ARE) activity depending on lifestyle in respect to physical activity. The study was performed on 46 young men divided into two groups: sedentary (S) and physically active (PA). All participants performed ME on a treadmill. PON1 activities, FRAP, uric acid, bilirubin, TBARS, and lipid profile were determined in their blood before, at the bout of, and after ME. No significant differences in PON1 activities were found between S and PA subjects at baseline. Nearly all biochemicals increased at ME in both groups. Both PON and ARE activity increased at the bout of ME in PA subjects and only ARE activity in S subjects. ARE/HDL-C ratio increased at the bout of ME in PA and S subjects. The difference in PON1 activity response to ME between study groups may be a result of adaptation of PA subjects to regular physical activity. We suggest that PON1 activity may be a marker of antioxidant protection at ME and an indicator of adaptation to exercise.
Highlights
Single strenuous physical activity leads to excessive free radical formation and oxidative stress [1]
The aim of our study was to compare the effect of maximal exercise (ME) on Paraoxonase 1 (PON1) activity in young men leading a different lifestyle in relation to their engagement in physical activity
Research was performed on 46 young men divided into two groups depending on their engagement in physical activity. 20 sedentary (S group) and 26 physically active (PA group) volunteers with an average of 3.5 years of regular training participated in the study
Summary
Single strenuous physical activity leads to excessive free radical formation and oxidative stress [1]. Regular physical activity is known to enhance antioxidant defense mechanisms. It is a recognized protective factor against the occurrence and progression of cardiovascular disease. Paraoxonase 1 (PON1) is a part of intrinsic antioxidant system It is an enzyme (EC.3.1.8.1, aryldialkylphosphatase) associated with HDL. The activity of the enzyme is known to depend on many factors, both genetic and environmental [6, 7]. The effect of exercise on PON1 activity may depend on the lifestyle of the examined population and the type and intensity of training. Understanding the role of PON1 in antioxidant mechanisms mobilized at physical activity will perhaps enable the prognosis of remote effects of exercise in sportsmen undertaking physical performance, as well as in subjects with increased risk of atherosclerosis. The relationship between PON1 activity and physical exercise may have practical implications
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