Aerobic Exercise Training Effects on Omentin-1, Insulin Resistance, and Lipid Profile Among Male Smokers

Abstract

ABSTRACT Background: Omentin-1 is a circulating adipokine that can serve as a biomarker for assessment of metabolic risk factors. We investigated the effect of eight weeks of aerobic exercise training on serum omentin-1, insulin resistance and lipid profile in nonsmokers and smokers. Methods: Nineteen male nonsmokers (aged 27.88 ± 2.47 years, and with BMI of 22.69 ± 1.77 kg.m−2) and twenty male smokers (aged 30.11 ± 1.96 years, and with BMI of 23.12 ± 1.91 kg.m−2) were randomly assigned into nonsmokers control group (C), nonsmokers exercise group (E), control smoker group (CS), and exercise smoker group (ES). Exercise groups participated in an eight-week aerobic exercise training program (three times a week, 20–35 min per session at 55%-70% of maximum heart rate). Serum omentin-1 and insulin values were determined by ELISA. The Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), glucose level and lipid profile were measured before and after the intervention. Pearson correlation test, Eta test, paired samples t-test, one and two-way analysis of variance (ANOVA) and post-hoc Tukey test were applied for data analysis (p < .05). Results: Aerobic exercise improved both serum omentin-1 and high lipoprotein cholesterol (HDL-C) in the exercise groups (P < .05). Also, exercise training reduced insulin, glucose, HOMA-IR, triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels (p < .05). Omentin-1 was significantly correlated with glucose, insulin, HOMA-IR, TG, TC, LDL-C and HDL-C in both nonsmokers and smokers. Conclusions: The findings suggest that aerobic exercise-induced changes in omentin-1 in the exercise-trained groups may be associated with the beneficial effects of exercise on reduced insulin resistance and lipid profile.