Aerobic capacity modulates adaptive thermogenesis: Contribution of non-resting energy expenditure

Abstract

Decreases in energy stores requires negative energy balance where caloric expenditure exceeds energy intake, which can induce adaptive thermogenesis—the reduction of energy expenditure (EE) beyond that accounted for by the weight lost. Adaptive thermogenesis varies between individuals. The component of total daily EE responsible for the interindividual variation in adaptive thermogenesis was investigated in this study, using a rat model that differs in obesity propensity and physical activity. Total daily EE and physical activity were examined before and after 21 days of 50% calorie restriction in male and female rats with lean and obesity-prone phenotypes—rats selectively bred for high and low intrinsic aerobic capacity (HCR and LCR, respectively). Calorie restriction significantly decreased EE more than was predicted by loss of weight and lean mass, demonstrating adaptive thermogenesis. Within sex, HCR and LCR did not significantly differ in resting EE. However, the calorie restriction-induced suppression in non-resting EE, which includes activity EE, was significantly greater in HCR than in LCR; this phenotypic difference was significant for both male and female rats. Calorie restriction also significantly suppressed physical activity levels more in HCR than LCR. When VO2max was assessed in male rats, calorie restriction significantly decreased O2 consumption without significantly affecting running performance (running time, distance), indicating increased energy efficiency. Percent weight loss did not significantly differ between groups. Altogether, these results suggest that individual differences in calorie restriction-induced adaptive thermogenesis may be accounted for by variation in aerobic capacity. Moreover, it is likely that activity EE, not resting or basal metabolism, may explain or predict the variation in individuals’ adaptive thermogenesis.