Abstract
Aerial Parts of Euphorbia hirta L. in Polar and Non-Polar Solvents: Phytochemical, Antioxidant and Glucose Uptake Studies for Potential Source of Adjunct Drug for Diabetes
Highlights
The study on natural products heavily relies on the existence of plant materials which contain secondary metabolites that exhibit valuable pharmacological applications.[1]
Ethyl acetate extract contains the highest flavonoids with 274.0 mg/g extract followed by acetone with 239.9 mg/g extract
Non-polar extracts (DCM and hexane) contain more flavonoids than polar extracts (EtOH, MeOH and H2O) with H2O extract being the lowest. These results showed that the total polyphenols and total flavonoids are relatively higher in slightly polar solvents like acetone, ethyl acetate and ethanol compared to polar solvents and nonpolar solvents (DCM and hexane)
Summary
The study on natural products heavily relies on the existence of plant materials which contain secondary metabolites that exhibit valuable pharmacological applications.[1]. Euphorbia contains 2000 species and is widely spread out through the tropical and subtropical climate zones such as Philippines and Taiwan.[2] One of the species that belongs to this genus is the Euphorbia hirta L. (E. hirta), known as Tawa-Tawa in the Philippines.[3] E. hirta can grow up to 80 cm tall, which is commonly erected, and is slender stemmed.[4] Preliminary phytochemical screening of the ethanol and methanol crude extracts showed that Tawa-Tawa contains notable components, such as alkaloids, flavonoids, terpenoids, tannins, phenols, and saponins, which have been proven to be biologically active in different studies, while the aqueous extract indicated the presence of carbohydrates.[5] The constituents of a plant material play a major role in the pharmacological properties that it exhibits.
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