AED Therapy in Pregnancy and Fetal Thyroid Levels

J Gordon Millichap

doi:10.15844/pedneurbriefs-10-8-12

Abstract

The neonatal screening results of TSH and 17-hydroxyprogesterone (17-OHP) in 34 study neonates born to mothers exposed to AEDs during pregnancy and their matched controls were evaluated at the Department of Paediatrics, Karolinska Institute, Stockholm, Sweden.

Highlights

OHP) in 34 study neonates born to mothers exposed to AEDs during pregnancy and their matched controls were evaluated at the Department of Paediatrics, Karolinska Institute, Stockholm, Sweden
The EEG at the start of the study was not predictive of relapse, but EEG worsening during the withdrawal of AEDs was associated with a significantly higher relapse rate
In this study of young adults with partial epilepsies, the EEG was predictive of relapse during but not before starting the withdrawal of antiepileptic drugs, especially if abnormalities appeared when previously absent

Summary

Introduction

VALUE OF EEG IN ANTIEPILEPTIC DRUG WITHDRAWAL The prognostic value of the EEG in 120 seizure-free epileptic patients, during and after antiepileptic drug withdrawal, was analyzed at the Department of Neurology, University of Bologna, Italy. Patients included had a history of partial epilepsies treated with AEDs for at least 2 years, and were seizure-free for at least 2 but not more than 6 years. The EEG at the start of the study was not predictive of relapse, but EEG worsening during the withdrawal of AEDs was associated with a significantly higher relapse rate.

Results

Conclusion