Abstract
Abstract For the sake of clarity it must first be stressed that the definition of adynamic (or aplastic) bone disease (ABD) and that of osteoporosis are based on criteria of different nature. Adynamic bone disease is a histopathological pattern which has been individualized among the various types of renal osteodystrophy by Sherrard et al. in hypercalcemic uremic patients because it did not coincide with formerly individualized entities, namely osteitis fibrosa, osteomalacia, and mixed lesions. In spite of hypercalcemia, osteoclastic bone resorption was not increased as in osteitis fibrosa, and in contrast to osteomalacia osteoid volume and thickness were not increased. Actually only osteoid surface may be increased in ABD. As in osteomalacia, however, osteoblastic surfaces were scarce or absent, explaining the low bone formation rate (BFR).
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