Abstract
The administration of a tricarbocyanine dye (Cardio-Green) for evaluation of cardiac output in three clinically uremic patients produced untoward symptoms (diaphoresis, pruritus, and headache) in two and a severe anaphylactoid reaction in a third. A fourth patient, on concomitant steroid treatment, had no reaction to the dye. Skin tests in all patients were negative, and gel diffusion studies failed to show precipitating antibodies in the serum of the patient with the anaphylactoid reaction. It is proposed that these reactions were more likely due to a nonimmunologic histamine releasing effect than to an antigen-antibody reaction.
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