Adverse reactions antituberculosis drugs for patients with pulmonary tuberculosis and the influencing factors

Abstract

Objective To analyze the adverse reactions of antituberculosis drugs for patients with pulmonary tuberculosis and the influencing factors. Methods From January, 2016 to December, 2018, 9 845 patients with pulmonary tuberculosis treated with antituberculosis drugs were selected. The incidence of adverse reactions was counted; the single factors of those with adverse reactions and those without were compared; and the influencing factors were analyzed. Results 2 908 (29.54%) of the 9 845 patients had adverse reactions, with no statistical differences in sex and BMI between the two groups (both P>0.05). More patients was over 69 years old and more had initial treatment, negative treatment, drinking history, and history of liver disease in those with adverse reactions than those without (all P 69 years old), treatment type (initial treatment), diagnosis type (smear negative), drinking history, and liver disease history were the risk factors of adverse reactions of antituberculosis drugs for the patients with pulmonary tuberculosis (OR > 1, P < 0.05). Conclusions Age, type of treatment, type of diagnosis, and history of liver disease are the influencing factors of adverse reactions of antituberculosis drugs for patients with pulmonary tuberculosis. We should pay attention to the high-risk group and take targeted measures to intervene. Key words: Pulmonary tuberculosis; Antituberculosis drug therapy; Adverse reactions; Influencing factors