Adverse pregnancy outcomes on the risk of overweight offspring: a population-based retrospective study in Xiamen, China

Yin-Ling Chen,Xiu-Lin Shi,Xue-Jun Li,Ming-Zhu Lin,Li-Li Han,Wei-Juan Su,Li-Ying Wang,Pei-Ying Huang,Hai-Qu Song,Wei Liu

doi:10.1038/s41598-020-58423-7

Abstract

The growth trajectory of Chinese preschoolers still remains unclear. Our objective was to determine whether there was an association between adverse pregnancy outcomes and overweight offspring. We analyzed population-based retrospective cohort data from the Medical Birth Registry of Xiamen, which comprised 33,157 children examined from 1 to 6 years of age. Longitudinal analyses were used to evaluate the growth trajectories of offspring body mass index (BMI). Multivariate logistic regression was used to assess the effects of two adverse pregnancy outcomes, gestational diabetes mellitus (GDM) and being large-for-gestational age (LGA), on childhood overweight. Offspring of mothers with GDM and LGA has a higher annual BMI z-score from 1 to 6 years of age (all P < 0.05). But, a higher annual BMI z-score was only observed in children aged 1–5 years in models 1–3. Overall BMI z-score of offspring aged 1–6 who were born to mothers with GDM and LGA were also higher in models 1–3 (all P < 0.05). Additionally, offspring of mothers with GDM and LGA had a higher risk for overweight in model 1, from 1 to 6 years of age (odds ratio (OR), 1.814; 95% confidence interval (CI), 1.657–1.985; P < 0.0001). However, this association was attenuated after adjusting for maternal pre-pregnancy BMI (OR, 1.270; 95% CI, 0.961–1.679; P = 0.0930). Offspring of mothers with GDM and LGA had a higher BMI z-score and increased risk for overweight. Indeed, intrauterine exposure to maternal GDM and LGA could bias offspring to overweight, whereas maternal pre-pregnancy BMI may play a key role in offspring overweight for children born to mothers with GDM and LGA.

Highlights

The growth trajectory of Chinese preschoolers still remains unclear
The incidence of gestational diabetes mellitus (GDM) is increasing worldwide, in China[6], and this is related to adverse pregnancy outcome such as large-for-gestational age (LGA) birth complications[7]
26,379 mothers qualified as non-GDM and appropriate-for-gestational age (AGA) (m-nonGDM-AGA), 5,179 mothers qualified as GDM and AGA (m-GDM-AGA), and 1,599 mothers qualified as GDM and LGA (m-GDMLGA) (Table 1)

Summary

Introduction

The growth trajectory of Chinese preschoolers still remains unclear. Our objective was to determine whether there was an association between adverse pregnancy outcomes and overweight offspring. Offspring of mothers with GDM and LGA had a higher risk for overweight in model 1, from 1 to 6 years of age (odds ratio (OR), 1.814; 95% confidence interval (CI), 1.657–1.985; P < 0.0001). This association was attenuated after adjusting for maternal pre-pregnancy BMI (OR, 1.270; 95% CI, 0.961–1.679; P = 0.0930). To our knowledge, there are no data available on childhood body mass index (BMI) z-scores in the Chinese population These data are necessary to understand the effect of GDM and LGA pregnancies on adverse childhood health outcomes including overweight or obesity, in this population. We conducted this study to track BMI z-score from infancy to early childhood (1–6 years) in a large population and to thereby determine the association between BMI z-score and offspring overweight with mother with GDM and LGA

Objectives

Methods

Results

Conclusion