Abstract
Adverse influence of ß-methylcholanthrene on detoxification function of chick embryo brain glutathione S-transferases and degenerative changes of brain
Highlights
Glutathione S-transferase (GST: EC 2.5.1.18) is an enzyme that can detoxify reactive metabolites like drugs and environmental chemicals, so that glutathione S-transferases (GSTs) is regarded as toxicologically crucial enzymes (Arakawa et al, 2013)
With the substrate p-NPA, GST specific activity was increased to 2.6 fold and 4.56 fold in response to 2 ppm and 4 ppm MC, but decreased to 2.13 fold in response to 6 ppm MC than 3.25 fold of control
GST isoenzymes expressed by the administration of MC, showed significant specific activity with the model substrates like BSP, p-NBC, p-NPA and CHP including CDNB
Summary
Glutathione S-transferase (GST: EC 2.5.1.18) is an enzyme that can detoxify reactive metabolites like drugs and environmental chemicals, so that GST is regarded as toxicologically crucial enzymes (Arakawa et al, 2013). GSTs are exhibiting multiple reactions with a multitude of endogenous and exogenous substrates (Salinas and Wong, 1999). GST super gene family is an important cellular defence enzyme against endogenous and exogenous toxic chemical compounds; some of them have carcinogenic potential (Ates et al, 1995; Strange and Fryer, 1999). GSTs are contributing in the phase II biotransformation of xenobiotics and carcinogens (Voso et al, 2008). In a review, Hayes and Pulford (1995) said that the GSTs are evolved to protect cell against reactive oxygen metabolites.
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