ADVERSE EVENTS ASSOCIATED WITH PLATELETPHERESIS: A PROSPECTIVE STUDY FROM A TERTIARY CARE HOSPITAL.

Abstract

Plateletpheresis is used to obtain platelets from volunteer donors, patient's family members,or donor with HLA or platelet antigen compatible phenotypes. To analyze the adverse reactions due to single donor platelet Aim: pheresis. Materials and Methods:This was a prospective observational study conducted over a period of one year from September 2018 to August 2019 in the department of Immunohematology and Blood Transfusion Medicine, GMC Jammu. A total of 157 plateletpheresis procedures were performed after taking informed and written consent from the donor. The donors were selected as per the guidelines of Director General of Health Services (DGHS). Single arm procedure was used.All the procedures were performed on Fresenius kabiCom.tec op 5/07.08 by intermittent flow centrifugation (IFC). The adverse events (AE's) were classified as donor related and kit/equipment related. A total Results: of 10 AE's were noted of which 6 (60%) events were associated with donors and 4 (40%) events were owned to fault in the kit/equipment.Donor related 6 AE's include citrate toxicity[n=3(50%)], vasovagal reactions [n=2(33.33%)] and hematoma [n=1(16.67%)].Machine related 4 AE's include leakage in the kit[n=3(75%)] and interface error [n=1(25%)]. Discussion and Conclusion: Our study showed (n=6)3.82% donor reactions and equipment related (n=4) 2.54% reactions. Apheresis donations performed on cell separators are safe. The percentage of reactions in our study was 6.36% and no serious adverse reaction was noted .But precautions and close monitoring helps to reduce such mild forms of reactions.Increasing demand of platelet transfusions for patients had led to accelerated use of Apheresis, cause of higher yield of platelets obtained from single donor.