Adverse effects of Typbar-typhoid conjugated vaccine in children vaccinated in university of Lahore teaching hospital

Abstract

Objective: To determine the frequency of adverse effects of Typbar TCV in children vaccinated in Hospital. Study design: Descriptive study Place & duration of study: Department of Pediatrics outpatient clinic, from 1 February to 2021 to 3rd March 2021. Methodology: Children aged 9 months to 15 years of age either gender coming for vaccination from 1st Feb-2021 to 17th Feb-2021 was included in study. Post vaccination Observation for 30 minutes was done for all children in hospital and were followed after 14 days on telephone for any local or systemic adverse effect after vaccination. Complications systemic and local were documented on proforma. All data was analyzed using SPSS 22. P-value calculation for change in percentage of adverse effects in the different age groups and gender Chi-square test was used. Results: In our study, total 835 children were enrolled out of which 666 responded. Contact with 169 children was not possible because their lack of response and unavailability. Mean age was 4.9±4.06 years. Regarding local adverse effects pain at site of injection was present in 30% children. Other local site reaction includes swelling in 17.7%, redness in 3% and limitation of movement in 2.4%. Systemic adverse effects included fever in 20.4%. Headache was present in 0.6% children. GI symptoms present in 0.9%. Conclusion: This study concluded that Typbar-TCV Typhoid Vi conjugate vaccine is safe among children aged 9 months to 15 years.