ADVERSE EFFECTS OF DICLOFENAC SODIUM ON KIDNEYS IN ADULT VOLUNTEERS

Abstract

The use of diclofenac sodium is a major concern in terms of renal function, patients were not given attention despite the clinical importance. This study aims to evaluate the prescribed doses (50mg/day) of diclofenac sodium by doctors for patients in the orthopedic unit.This study was conducted on 36 volunteers, male and female, who were randomly selected from the orthopedic out-patient department and were divided into two groups (two treatments). The first group (18 volunteers) received diclofenac sodium 50 mg and the second group did not receive any medicine (control). The age of volunteers in this study ranged between 20 years to 59 years, both male and female, from September 2020 to September 2021.The main indicators to detect toxic effects of diclofenac sodium on kidney function were urea, uric acid, and creatinine. The urea level in this study was 27mg/dL in the first group and 25mg/dL in the control. Uric acid was 4.12mg/dL in the first treatment and 4.04mg/dL in control and Creatinine level was 0.55mg/dL and control treatment was 0.48mg/dL .All these values collected from the study are within the normal range and cause no pathological or renal disorder.