Abstract
Adverse effects of bolus fluid resuscitation—short-term benefit but long-term harm
Highlights
11 Disselhorst MJ, Quispel-Janssen J, Lalezari F, et al Ipilimumab and nivolumab in the treatment of recurrent malignant pleural mesothelioma (INITIATE): results of a prospective, single-arm, phase 2 trial
Fluid Expansion as Supportive Therapy (FEAST), which was done in children with compensated febrile hypotension in resource-poor conditions, involved the administration of boluses of 0·9% sodium chloride or 5% albumin, which significantly increased 48 h mortality when compared with patients who did not receive fluid boluses
A post-hoc analysis of the FEAST data[3] that characterised study patients according to the presenting syndrome and the nature of the terminal clinical event showed that the highest mortality occurred in patients with severe shock and acidosis
Summary
11 Disselhorst MJ, Quispel-Janssen J, Lalezari F, et al Ipilimumab and nivolumab in the treatment of recurrent malignant pleural mesothelioma (INITIATE): results of a prospective, single-arm, phase 2 trial. The results of the Fluid Expansion as Supportive Therapy (FEAST) trial[1] provide compelling evidence about the safety and efficacy of bolus fluid resuscitation in certain patient populations. A post-hoc analysis of the FEAST data[3] that characterised study patients according to the presenting syndrome and the nature of the terminal clinical event showed that the highest mortality occurred in patients with severe shock and acidosis.
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