Adverse Effects of Androgen Deprivation in Elderly Men with Prostate Cancer

Abstract

The purpose of this review is to summarize the key literature of complications and adverse effects experienced by elderly men undergoing androgen deprivation therapy for prostate cancer, as well as evidence-based strategies to manage these complications. Current research demonstrates several adverse effects associated with treatment with androgen deprivation therapy, including skeletal complications, possible cardiovascular effects, diabetes and metabolic complications, decreased sexual function and libido, depression, and cognitive decline. Despite the well-known side effect profile of androgen deprivation therapy for prostate cancer, little evidence-based guidance for management of these complications exists outside of skeletal health. Prospective studies are needed to determine the effect of androgen deprivation therapy on cardiovascular disease in older adults, and prospective trials are needed to assess diagnostic and therapeutic interventions in this large, vulnerable patient population.