Abstract
Objectives: In this cross-sectional study, the aims were to analyze the incidence and pattern of adverse drug reactions (ADRs) of antiepileptic drugs in pediatric patient. Most common adverse effect and most common drug causing adverse effect were evaluated. Methods: Study was conducted over 60 Patients for 6 months in out-patient basis pediatric department in Rajindra Hospital associated with GMC, Patiala, a tertiary care teaching hospital in Punjab. The patient diagnosed by the Pediatrician with epilepsy who fulfilling inclusion and exclusion criteria was enrolled after taking informed consent. ADRs were noted using Pediatric Epilepsy Side Effect Questionnaire at clinic visit and any other adverse effects reported by patients. Results: In this study, a total of 60 children were enrolled. The mean age was 10.26±3.70, median were 11.00. 41 (68.33%) patients were boys and 19 (31.67%) were girls. In Cognitive ADRs with anti-epileptic drugs, there were total 17 ADRs reported. Valproate was causing most cognitive ADRs (32.43%). Among all cognitive ADRs, attention difficulty was the commonest complains. There were no motor and behavioral ADRs reported. Total 27 general neurological ADRs reported, which was highest reported ADRs. Among general neurological, Clobazam was causing highest ADRs (55.56%). 10 patients also reported tremor as another ADR and Clobazam causing most (22.22%). Conclusion: In the present study, boys were developing more epilepsy than girls. Valproate was causing most ADRs. Among all cognitive ADRs, attention difficulty was the most common ADR. General neurological ADRs were highest reported ADRs.
Highlights
Epilepsy is one of the most common serious neurological disorders [1]
It has been estimated that 70% of all epilepsy syndrome start between the age of 0 and 19 years and 30% of the children with seizure will have their first episode before the age of 4 years, and more than half of the children with epilepsy will have more than one type of seizure [5]
This study will be helpful to analyze the therapeutic benefit for the patient. Study design This cross-sectional study was conducted in out-patient in pediatric department in Rajindra Hospital associated with GMC, Patiala, a tertiary care teaching hospital in Punjab
Summary
Epilepsy is one of the most common serious neurological disorders [1]. Seizures often cause transient impairment of awareness, leaving the individual at risk of bodily harm and often interfering with education and employment [2].In the mid-1800 s, the first effective anti-seizures medication, Bromide, was introduced. Epilepsy is one of the most common serious neurological disorders [1]. 5–10% of the population will have at least one seizure, with the highest incidence occurring in early childhood and late childhood [3]. The prevalence of epilepsy has been estimated at 5–30 persons per 1000 [4]. The median incidence for children aged 0–14 years is 0.822/1000 children. It has been estimated that 70% of all epilepsy syndrome start between the age of 0 and 19 years and 30% of the children with seizure will have their first episode before the age of 4 years, and more than half of the children with epilepsy will have more than one type of seizure [5]. Crude prevalence rate for active epilepsy was 7.44/1000 population in Punjab [6]
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