Adverse Drug Reactions in Norway: A Systematic Review.

Vaismoradi Vaismoradi,Logan Logan,Sletvold Sletvold,Jordan Jordan

doi:10.3390/pharmacy7030102

Vaismoradi Vaismoradi, Logan Logan + Show 2 more

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https://doi.org/10.3390/pharmacy7030102

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Abstract

Prescription medicines aim to relieve patients’ suffering but they can be associated with adverse side effects or adverse drug reactions (ADRs). ADRs are an important cause of hospital admissions and a financial burden on healthcare systems across the globe. There is little integrative and collective knowledge on ADR reporting and monitoring in the Norwegian healthcare system. Accordingly, this systematic review aims to investigate the current trends in ADR reporting, monitoring, and handling in the Norwegian healthcare system and describe related interventions. Appropriate keywords, with regard to ADRs in both English and Norwegian languages, were used to retrieve articles published from 2010 to 2019. Six articles met the inclusion criteria. The findings offer a comprehensive picture of ADR reporting and monitoring in the Norwegian healthcare system. Psychotropic medicines were most commonly implicated by patients, while professionals most commonly reported ADRs associated with anticoagulants. The current ADR systems were compiled with the involvement of both patients and healthcare providers to record all types of drugs and ADRs of various severities, and aimed at improving ADR tracking. However, there is a need to improve current initiatives in terms of feedback and quality, and more studies are needed to explore how ADR profiles, and the associated vigilance, can improve the safety of medicines management in Norway.

Highlights

IntroductionThe prescription and administration of medicines aims to relieve patients’ suffering and ailments
The prescription and administration of medicines aims to relieve patients’ suffering and ailments. They can be associated with adverse side effects or adverse drug reactions (ADRs) that lead to physical and psychological harm, much of which can be prevented
World Health Organization (WHO) as an unintended reaction in the patient to a medicine associated with any dose administered by the healthcare provider [1]

Summary

Introduction

The prescription and administration of medicines aims to relieve patients’ suffering and ailments. They can be associated with adverse side effects or adverse drug reactions (ADRs) that lead to physical and psychological harm, much of which can be prevented. World Health Organization (WHO) as an unintended reaction in the patient to a medicine associated with any dose administered by the healthcare provider [1]. Serious ADRs are those that can result in life-threatening conditions, persistent or significant disability, prolonged hospitalization, congenital anomalies or death [2]. ADRs [3,4,5]. ADRs cause 5–8% of unplanned hospital admissions in the UK and cost £2.5 billion each year [6,7]. Many patients benefit from prescribed medicines [8], but the high prevalence of ADRs (7.2–8.4%) in community or ambulatory care settings is a challenge to successful medicines management and patient safety strategies [9]

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