Adverse Drug Reaction Monitoring of Antipsychotic Drugs and Mood Stabilizers in a Teaching Hospital

Swetha Munoli,Soumya B Patil

doi:10.5530/ijpcs.5.4.5

Abstract

International Journal of Pharmacology and Clinical Sciences,2016,5,4,118-121.DOI:10.5530/ijpcs.5.4.5Published:December 2016Type:Research ArticleAuthors:Swetha Munoli, and Soumya B Patil Author(s) affiliations:Swetha Munoli1, Soumya B Patil2* 1Department of Pharmacology, ESIC-MC and PGIMSR, Bangalore, Karnataka, INDIA. 2Department of Pharmacology, Navodaya Medical College, Raichur, Karnataka, INDIA. Abstract:Background: Antipsychotics and mood stabilizers are associated with adverse effects which can affect the compliance and course of treatment in mental disorders. The present study was therefore undertaken to monitor the adverse drug reactions (ADRs) of the antipsychotics and mood stabilizers in the psychiatric outpatient unit of our hospital. Methods: Study was conducted from December 2011 to November 2012, the patients on antipsychotic drugs from psychiatry outpatient department (OPD) of Raichur Institute of Medical Sciences were considered for analysis. The patients were diagnosed by consultant psychiatrist. Data was collected in standard questionnaire format. All patients diagnosed with psychiatric disorder as per ICD 10 criteria and receiving treatment with antipsychotic or mood stabilizer were included. Assessment of causality and severity of recorded adverse events was done using WHO assessment scale and modified Siegel and Hartwig Scale respectively. Results: 45 ADRs were recorded among 778 patients. Extra pyramidal symptoms, anticholinergic side effects and Weight gain were the most common ADRs. Risperidone, chlorpromazine and olanzapine were the drugs causing maximum ADRs. Assessment of causality and severity of recorded adverse events showed possible to probable and mild to moderately severe respectively. Conclusion: Extrapyramidal symptoms were most common ADRs in our study followed by anticholinergic side effects. Risperidone was most commonly prescribed drug followed by chlorpromazine. Risperidone and chlorpromazine accounted for most of ADRs. Assessment of causality of recorded adverse events showed no certain cause and Assessment of severity of recorded adverse events showed no severe cases. Keywords:Antipsychotics, Extrapyramidal Symptoms, Haloperidol, Lithium, Olanzapine, RisperidoneView:PDF (288.48 KB) PDFClick here to download the PDF file. Images Incidence rate of adverse effects with various anti psychotic drugs

Highlights

According to WHO, adverse drug reaction is defined as “Any response to a drug which is noxious and unintended, and which occurs at doses normally used in man for prophylaxis, diagnosis, or therapy of disease, or for the modification of physiological function”[1] Adverse drug reactions (ADRs) are known to be the significant cause of morbidity and mortality both inpatients and outpatients settings.[2]
Many international studies have reported an overall incidence rate of 5.01–21.45% in psychiatry outpatient department (OPD). [12,13,14,15,16] There were more male patients who developed adverse drug reactions (ADRs), this is in contrast to the findings of previous studies[17,18] and similar to a study by Sengupta et al, and Jain, et al where more males developed ADRs than females.[12,13,14,15,16,17,18,19] 32 out of these 41 patients belonged to 21-40 years age group
The most common antipsychotic drugs associated with ADR was risperidone followed by chlorpromazine and olanzapine

Summary

Introduction

According to WHO, adverse drug reaction is defined as “Any response to a drug which is noxious and unintended, and which occurs at doses normally used in man for prophylaxis, diagnosis, or therapy of disease, or for the modification of physiological function”[1] Adverse drug reactions (ADRs) are known to be the significant cause of morbidity and mortality both inpatients and outpatients settings.[2]. Antipsychotics and mood stabilizers are associated with adverse effects which can affect the compliance and course of treatment in mental disorders. The present study was undertaken to monitor the adverse drug reactions (ADRs) of the antipsychotics and mood stabilizers in the psychiatric outpatient unit of our hospital. All patients diagnosed with psychiatric disorder as per ICD 10 criteria and receiving treatment with antipsychotic or mood stabilizer were included. Anticholinergic side effects and Weight gain were the most common ADRs. Risperidone, chlorpromazine and olanzapine were the drugs causing maximum ADRs. Assessment of causality and severity of recorded adverse events showed possible to probable and mild to moderately severe respectively. Conclusion: Extrapyramidal symptoms were most common ADRs in our study followed by anticholinergic side effects.

Methods

Results

Conclusion