Abstract
INTRODUCTION: Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. METHODS: We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate the factors associated with ADEs. RESULTS: ADEs were described in 102 medical notes (31.9%). Captopril was most frequently associated with ADEs. Age (RR 0.96; 95%CI 0.94-0.99) and cardiac C/D stages (RR 3.24; 95%CI 1.30-4.58) were the most important clinical factors associated with ADEs. CONCLUSIONS: Close follow-up is warranted for CD patients.
Highlights
We aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients
The present study aimed to identify factors that might be associated with ADEs among patients with chronic CD
28 (8.8%) cases of cough were observed and classified as adverse reactions related to captopril use, a finding that is very similar to that of Hamad et al 9 (5%)
Summary
Adverse drug events and the associated factors in patients with chronic Chagas disease Luiza Braz da Cunha Lopes[1]*, Raquel Rodrigues Pereira[1]*, Patricia Mello Andrade[1]*, Fernanda Martins Carneiro[1]*, Mauro Felippe Felix Mediano[1]*, Sophia Isabel Linnemann Kilgore[1]*, Alejandro Marcel Hasslocher-Moreno[1]*, Andréa Silvestre de Sousa[1]*, Manoel Marques Evangelista Oliveira[2]*, Roberto Magalhães Saraiva[1]*, Marcelo Teixeira de Holanda[1]* and Gilberto Marcelo Sperandio da Silva[1]*. Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, RJ, Brasil. Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Revista da Sociedade Brasileira de Medicina Tropical
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
