Abstract
Inflammation and the oxidative stress are two main notorious driving forces behind the disease progression, deterioration and eventually the death of the individuals concerned. When these two aggravating factors have been effectively addressed, then the disorders affecting people can be under control and relief for the treating clinician. The patients can experience an improvement in health-related quality of life, or better total remission. This review evaluates the relation between oxidative stress in critically ill patients, vitamin C intake as an antioxidant and severity of illness. It also highlights the implications of these two processes in major disease areas, such as cancer, intensive care, sepsis, cardiology, rheumatology, and the damaging outcomes of the imbalance between the production of ROS and antioxidants.
 Citation: Herbert E, Fournier D. Adverse clinical impact and outcome of inflammation and oxidative stress: Are the antioxidant properties of vitamin C helpful? Anaesth. pain intensive care 2022;26(4):710-719.
 DOI: 10.35975/apic.v26i5.1993
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