ADVANTAGES OF NOVEL DRUG DELIVERY SYSTEM AND SILVER NANOPARTICLES FOR HERBAL DRUGS; AND MEDICINAL IMPORTANCE OF Crotalaria burhia PLANT: A REVIEW

Abstract

Herbal or natural medicines have been used since ancient time due to easy availability and less side effects. Still 80% population of developing countries uses herbal medicines to treat common diseases. The Crotalaria burhia plant is shrub having several chemical constituents like flavonoids, hormones, alkaloids phenolic compounds and terpenes etc. It traditionally used for fever, inflammation, chronic kidney pain, cancer, general bacterial infections, fungal infections, gout, cough, arthritis, diarrhea, abdominal pain, nausea, and typhoid etc. It has also been used in cattle for the removal of placenta after delivery. Due to traditional dosage formulation a few amount of drug reach to its target tissue. In recent past, Phyto-pharmaceutical work leads to new medicine delivery methods for example nanoparticles, microparticles, nano-suspension and liposome’s etc. For herbal medicine, this unique medication delivery mechanism enhances stability, solubility, absorption, bioavailability and therapeutic effect. The carrier in nano dosage forms increases the drug concentration at targeted tissue due to which systemic side effects can be reduced. Silver nanoparticles have been emerged as a potent component of novel drug delivery system because silver nanoparticles (Ag NPs) have its own antimicrobial and anticancer activities but they are non-toxic to human body. Ag NPs synthesized by natural plant extracts have shown enhanced anticancer and antimicrobial activities. The silver nanoparticles exert its antimicrobial and anticancer activity by disrupting cell wall permeability and cellular respiration. Recently use of Ag NPs has been increased to overcome the antibiotics resistance. Silver nanoparticles have ability to sterilize the hospital items. This new method of drug delivery is a protective way for administration of herbal drugs to target tissues.