Abstract
Background: most of the gynaecological interventions are generally done under regional anaesthesia. Currently dexmedetomidine came out as a beneficial adjunct for regional analgesia as well as anaesthesia. It is a highly selective α-2 agonist. Aims & objectives: to compare the effects & behavior of dexmedetomidine with clonidine when both are used with bupivacaine for spinal analgesia. Material and Methods: 100 cases of ASA grade 1 & 2 who were undergoing elective gynaecological surgical intervention were studied. They were divided into two groups (50 each). Group I received combination of bupivacaine & clonidine while group II received combination of bupivacaine + dexmedetomidine. Results: Average duration of onset of sensory block was earlier in group II. Arrival of motor block in Group I was slightly on lower side than Group II. Ten cases in Group I and eighteen cases from group II had notable bradycardia and hypotension. Discussion: Our study concludes that dexmedetomidine when used in combination with bupivacaine is very effective in gynaecological surgical interventions that demand longer duration & have comparatively lesser side effects.
 Keywords: dexmedetomidine, clonidine, Bupivacaine, gynaecological procedures.
Highlights
Whereas motor block was earlier in group I where clonidine was used in combination with bupivacaine
When we compare the duration of sensory block, duration of motor block & the duration of spinal anesthesia, dexmedetomidine definitely have an upper edge over clonidine
None of the female experienced any kind of respiratory distress & sp[02] of all of them was constantly maintained above 96%
Summary
Written informed consent was taken improvement in various anesthetic techniques. Lots of from each & every study subject. Those individuals who combinations of anesthetic agents have been tried and were having past history of any cardiac illness, deranged tested with variable success rates. Most of the renal function or any hepatic anomaly or any history of gynaecological surgical interventions are done under regional anesthesia[1,2]. Bupivacaine is very commonly used hypersensitivity to anaesthetic agent were excluded from our study. They were divided into two groups of 50 each
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