Advantages of individual approach to chronotherapy in Yamal hypertensive shift workers

Abstract

Objective. To compare efficiency of the chronotherapy based on spectral analysis of blood pressure (BP) with chronotherapy based on the results of 24-hour BP monitoring. Design and methods. Ninety-three men, transpolar shift workers, with hypertension (HTN) II stage, 1–2 degree were divided into 2 subgroups: in the 1st group daily BP profile was assessed once («dipper», «non-dipper», «over-dipper», «night-peaker», «Standard treatment» group, n = 57), in the 2nd group BP chronotype was considered (group «Chrono», n = 36). Standard analysis and cosinor-analysis of 24‑hour BP monitoring were performed. Lisinopril (LP) 5 mg per day was prescribed for 2 weeks followed by second assessment. Results. Chronotherapy based on the chronotype of daily BP and its spectral characteristics is more efficient and allows better BP control. It leads to a better compliance and achievement of the target BP level, normalization of daily dynamics of BP and heart rate. Conclusions. In shift workers living in the Far North, chronotherapy of HTN is a promising method used due to the early change of daily BP dynamics. Individual chronotherapy is recommended as a rational approach to treat “northern” HTN and contributes to a better patients’ compliance.