Advantage of Adrenomedullin as remedial contrivance for left ventricular remodeling after acute myocardial infarction

Abstract

Adrenomedullin is a potent vasoactive and natriuretic peptide normally found in human plasma and secreted by adipocytes that interfere with lipolysis through nitroxide-mediated oxidation. The level of adrenomedullin becomes high in patients with acute myocardial infarction. It has also been reported to inhibit the growth of cardiac myocytes as well as fibroblasts. In recent studies, it has been reported that the long-term administration of adrenomedullin has a significant effect on left ventricular remodeling and hormonal homeostasis, as well as on hemodynamics in the experimental subject. On the basis of recent studies, it is known that activation of protein kinase attenuates ischemia-reperfusion injury of myocardial origin. However, adrenomedullin is also known as a powerful activator of protein kinase Akt imparting cardioprotective effects. The long-term continuous administration of adrenomedullin has a significant effect on left ventricular remodeling and hemodynamics. Based on this effect, it would be worthwhile to utilize this peptide as useful therapeutic for the management of acute myocardial infarction. Moreover, the adrenomedullin is also known for its vasodilatory and stabilization properties referring to endothelial barriers.