Abstract
In humans, the capacity of viruses to infiltrate multiple organs and cause extensive damage is well-established. However, our comprehension of viral infection pathogenesis within the central nervous system (CNS) remains limited due to challenges in accessing clinical research specimens and the inherent constraints of animal models. Derived from either human embryonic stem cells (hESCs) or human-induced pluripotent stem cells (hiPSCs), human brain organoids undergo meticulous differentiation in culture media that simulate the developmental environment of the brain, characterized by their structural intricacy and diverse cell types. The evolution of human brain organoids has undoubtedly provided the scientific community with a potent research tool for investigating neurological diseases. We summarizes research findings on viral infection models based on human brain organoids. Furthermore, we discuss the limitations of this model and envision future developments and applications of human brain organoids.
Published Version
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