Abstract
There is an increasing burden of responsibility for intensivists to optimize donation potential after the declaration of brain death in patients with catastrophic brain injury. Best practice for donor management, if present, has been formed on low quality and mainly observational studies or consensus. In particular, research into the use of corticosteroids has shown varied benefit. The specific and limited results of the CORTICOME study are less important than the systematic methodology and the development of rigour in the study of deceased organ donation. Donor management would benefit from continued systematic analysis of current literature, understanding of the physiologic basis for therapy, and further prospective controlled trials. Worldwide collaboration partnerships and funding are needed to optimize the management of deceased organ donation.
Highlights
There is an increasing burden of responsibility for intensivists to optimize donation potential after the declaration of brain death in patients with catastrophic brain injury
* Correspondence: sdhanani@cheo.on.ca 1Pediatric Critical Care, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada K1H 8L1 2Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1N 6N5 Full list of author information is available at the end of the article positive impact on organ transplantability when meeting donor management goals is significant [3]
Pinsard and colleagues should be commended for accomplishing the challenging task of conducting a prospective multi-centre study involving 259 subjects in order to identify the benefits of low-dose corticosteroids after brain death
Summary
There is an increasing burden of responsibility for intensivists to optimize donation potential after the declaration of brain death in patients with catastrophic brain injury. Pinsard and colleagues [1] have completed a prospective multi-centre study showing the benefits of low-dose corticosteroids after brain death. * Correspondence: sdhanani@cheo.on.ca 1Pediatric Critical Care, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada K1H 8L1 2Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1N 6N5 Full list of author information is available at the end of the article positive impact on organ transplantability when meeting donor management goals is significant [3].
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